Dogs will be always pursuing cats, while these will be after the rats. This is a fact in this life, with only a few exceptions, and is exactly what happens in the Tom and Jerry cartoon episodes and also in their games. Even though the dog Spike doesn't appear much to save Jerry from Tom's hands, the rat can easily find a way out of every bad situation and put the blame on the cat, who is almost kicked out of the house by his owner every time. As any other mouse, our smart character loves to eat cheese and therefore he can always be found trying to steal a piece or a dozen from the fridge when his enemy is sleeping or distracted, sometimes counting with the help of his nephew, the gray mouse called Nibbles, who is small but can eat ten times more than our main character's belly can take. Running away from their natural enemy is a must when they appear in the adventure games of their own show, counting on the player's help to reach the hole in the wall where they live before the protector of the house manages to catch them. Deep inside, they are all friends and, even though they fight and brawl sometimes, they can always count on one another when the difficult times come or to have some fun when everybody had lunch, racing with karts and maybe going on a journey inside a platform game made with them all.
Resources: Oggy games